Wedgewood is expected to play the full 60 minutes against the Blue Jackets tonight, Chris Ryndak of Sabres.com reports.
After playing on Jack Eichel's line in the previous game, Okposo will start tonight's contest lower on the depth chart.
Mittelstadt is still looking to get his first point of the preseason after being held off the scoresheet in his previous two contests.
Hutton made 28 saves in Saturday's 3-2 loss to Toronto.
Skinner scored his first goal since being traded to the Sabres by the Hurricanes in Saturday's 3-2 loss to the Maple Leafs.
Eichel tallied two assists in Saturday's 3-2 loss to the Maple Leafs.
Bogosian is in the lineup for Saturday's tilt against Toronto, Mike Harrington of TBNSports reports.
Hutton is the likely starter for Saturday's preseason contest against Toronto, Mike Harrington of TBNSports reports.
Ullmark set aside 27 of 31 shots in Friday's 5-3 preseason road loss to the Maple Leafs.
Smith registered a highlight-worthy goal in Friday's 5-3 preseason road loss to the Maple Leafs.
Oglevie gathered a rebound for his second goal of the preseason Friday, but the Sabres lost to the Maple Leafs on the road, 5-3.
Moulson was waived by the Sabres on Friday, Renaud Lavoie of TVA Sports reports.
Ullmark is listed atop the projected goalie order for Friday's preseason road clash with the Maple Leafs. As a result, he's expected to get the starting nod.
Hunwick (neck) is expected to be out for Opening Night against Boston on Oct. 4, Bill Hoppe of the Olean Times Herald reports.
General manager Jason Botterill told reporters that Sheary (upper body) could be ready in time for Opening Night against Boston on Oct. 4, Bill Hoppe of the Olean Times Herald reports.
Bogosian (hip) is scheduled to practice Thursday, John Vogl of The Athletic reports.
Reinhart signed a two-year contract with the Sabres on Wednesday, with the deal valued at $3.65 million annually.
Wedgewood allowed two goals on 12 shots in the third period against the Penguins on Tuesday. The Sabres won 3-2.
Hutton made 14 saves, holding the Penguins off the scoreboard through two periods in a 3-2 preseason victory on Tuesday.
Eichel filled the stat sheet with a short-handed goal, four shots, two penalty minutes, two hits and a block in Tuesday's 3-2 preseason victory against the Penguins.
McCabe (shoulder) is active for Tuesday's preseason home game versus the Penguins.
Girgensons (face) is in the lineup Tuesday for a preseason home game versus the Penguins.
Bailey (shoulder) is expected to play in Tuesday's preseason home game versus the Penguins.
Hutton is slated to get the start versus the Penguins on Tuesday.
Bogosian (hip) is day-to-day, but he's on track to resume skating Wednesday, Bill Hoppe of the Olean Times Herald reports.