5:17 PM - Christian McCaffrey (SF) 49ers placed McCaffrey (knee) on injured reserve Tuesday.

4:46 PM - Christian McCaffrey (SF) 49ers placed McCaffrey (knee) on injured reserve Monday, Ian Rapoport of NFL Network reports.

5:18 PM - Christian McCaffrey (SF) (Achilles) doesn't have an injury designation for Sunday's game against Seattle, Cam Inman of The San Jose Mercury News reports.

4:49 PM - Christian McCaffrey (SF) Kyle Shanahan said McCaffrey (Achilles) will be a limited practice participant Wednesday, Nick Wagoner of ESPN.com reports.

4:26 PM - Christian McCaffrey (SF) (Achilles) rushed 13 times for 39 yards and caught six of seven targets for 68 yards in Sunday's 23-20 win over Tampa Bay.

11:34 AM - Christian McCaffrey (SF) (Achilles) is listed as active Sunday at Tampa Bay, Lindsey Pallares of the 49ers' official site reports.

9:34 AM - Christian McCaffrey (SF) (Achilles) remains listed as questionable for Sunday's game against the Buccaneers, but he's on track to play and expressed confidence that he's take on his usual workload in his season debut, Mike Garafolo of NFL Network reports.

4:07 PM - Christian McCaffrey (SF) (Achilles) was activated off injured reserve Saturday, Adam Schefter of ESPN reports.

4:45 PM - Christian McCaffrey (SF) (Achilles) is listed as questionable for Sunday's game at Tampa Bay, with coach Kyle Shanahan saying Friday that the running back will play, Eric Branch of the San Francisco Chronicle reports.

6:58 PM - Christian McCaffrey (SF) Kyle Shanahan said Thursday that he expects McCaffrey (Achilles) to make his season debut Sunday at Tampa Bay, David Lombardi of The San Francisco Standard reports.

6:35 PM - Christian McCaffrey (SF) (Achilles) was limited at Thursday's practice, Nick Wagoner of ESPN.com reports.

4:09 PM - Christian McCaffrey (SF) Kyle Shanahan said McCaffrey will be limited at Wednesday's practice, but the running back has exhibited "no pain" with his Achilles, Adam Schefter of ESPN reports.

2:16 PM - Christian McCaffrey (SF) 49ers designated McCaffrey (Achilles) to return from injured reserve Monday.

9:50 AM - Christian McCaffrey (SF) Francisco head coach Kyle Shanahan said Monday that McCaffrey (Achilles) will remain in the Bay Area during the 49ers' Week 9 bye to take part in "simulated practice stuff," Nick Wagoner of ESPN.com reports. "It depends how this week goes," Shanahan said, when asked if McCaffrey will be available to make his season debut Week 10 at Tampa Bay. "He's had no setbacks, so it looks like we're on track, but he's going to hit it hard this week while we're gone...as long as it all goes good, hopefully we'll get him back in practice next week."

12:04 PM - Christian McCaffrey (SF) (Achilles) is on track to participate in a "bonus" practice that the 49ers have scheduled during their Week 9 bye, Ian Rapoport of NFL Network reports.

7:08 PM - Christian McCaffrey (SF) Kyle Shanahan said Monday that McCaffrey (Achilles) is unlikely to practice this week, but the 49ers are hopeful the running back will be able to return after their Week 9 bye on Sunday, Nov. 10 at Tampa Bay, Nick Wagoner of ESPN.com reports.

3:11 PM - Christian McCaffrey (SF) Kyle Shanahan said Friday that McCaffrey (Achilles) won't return to practice next week, Nick Wagoner of ESPN.com reports.

7:08 PM - Christian McCaffrey (SF) Kyle Shanahan said Monday that McCaffrey is tending to tendinitis in both of his Achilles, Nick Wagoner of ESPN.com reports. "I think it started in one, and you overcompensate, it went to the other," Shanahan added. "Mainly one of them has just been bothering him, but he's had it in both."

9:58 AM - Christian McCaffrey (SF) a chance McCaffrey (Achilles) could run on hard ground this coming week, Ian Rapoport of NFL Network reports.

5:34 PM - Christian McCaffrey (SF) Kyle Shanahan said Friday that McCaffrey (Achilles) may "start hitting the rehab here harder on Monday," Nick Wagoner of ESPN.com reports.

7:34 PM - Christian McCaffrey (SF) Kyle Shanahan said Thursday on 104.5 KNBR that the 49ers will "probably turn it up here in the next couple of weeks" with McCaffrey (calf/Achilles). "We'll start testing it out here sooner rather than later," Shanahan added.

6:53 PM - Christian McCaffrey (SF) Kyle Shanahan said Monday that McCaffrey is in Germany to visit with a specialist for his Achilles tendinitis, Nick Wagoner of ESPN.com reports.

9:36 AM - Christian McCaffrey (SF) (calf), who was placed on injured reserve Saturday, is "likely to be out six weeks or potentially more" while he recovers from Achilles tendinitis, Ian Rapoport of NFL Network reports.

1:26 PM - Christian McCaffrey (SF) Schefter of ESPN reports that McCaffrey (Achilles/calf) will be placed on injured reserve Saturday.

7:28 PM - Christian McCaffrey (SF) 49ers may place McCaffrey (calf/Achilles) on injured reserve Saturday, Ian Rapoport of NFL Network reports.

5:06 PM - Christian McCaffrey (SF) has been ruled out for Sunday's game against the Vikings. The 49ers are considering playing him on injured reserve, which would sideline him this week plus three more games, Tom Pelissero of NFL Network reports.

3:53 PM - Christian McCaffrey (SF) (Achilles) is not present at the portion of Friday's practice open to the media, Nick Wagoner of ESPN.com reports.

11:18 AM - Christian McCaffrey (SF) GM John Lynch said Friday morning that he doesn't know if McCaffrey (Achilles) will play Sunday at the Vikings, Cam Inman of The San Jose Mercury News reports.

6:58 PM - Christian McCaffrey (SF) (calf/Achilles) remained limited at Thursday's practice, Adam Caplan of SiriusXM NFL Radio reports.

4:20 PM - Christian McCaffrey (SF) (Achilles/calf) is in uniform and expected to participate in Thursday's practice, Cam Inman of The San Jose Mercury News reports.

3:54 PM - Christian McCaffrey (SF) Kyle Shanahan said McCaffrey (calf/Achilles) will be a limited practice participant Wednesday, Cam Inman of The San Jose Mercury News reports.

9:32 AM - Christian McCaffrey (SF) (Achilles/calf) appears to be a "long shot" to play Sunday against the Vikings, sources tell Ian Rapoport of NFL Network reports.

2:27 PM - Christian McCaffrey (SF) Francisco head coach Kyle Shanahan labeled McCaffrey (calf/Achilles) as day-to-day heading into Sunday's game against the Vikings, Nick Wagoner of ESPN.com reports.

6:56 PM - Christian McCaffrey (SF) (calf/Achilles) is listed as inactive Monday against the Jets, Lindsey Pallares of the 49ers' official site reports.

6:53 PM - Christian McCaffrey (SF) (calf/Achilles) is in line to be inactive Monday against the Jets, Mike Garafolo of NFL Network reports.

10:18 AM - Christian McCaffrey (SF) (calf/Achilles) remains listed as questionable, but he expects to play Monday against the Jets and handle something close to a normal workload, Ian Rapoport of NFL Network reports.

4:57 PM - Christian McCaffrey (SF) (calf/Achilles) is listed as questionable for Monday's game against the Jets, Nick Wagoner of ESPN.com reports.

6:57 PM - Christian McCaffrey (SF) (calf/Achilles) said Friday that he has no doubt he'll play Monday against the Jets, Nick Wagoner of ESPN.com reports.

6:40 PM - Christian McCaffrey (SF) (calf) was a limited practice participant Friday, Nick Wagoner of ESPN.com reports.

4:46 PM - Christian McCaffrey (SF) (calf/Achilles) is practicing Friday and appears to be "moving at full speed with no issue," according to Nick Wagoner of ESPN.com.

11:42 AM - Christian McCaffrey (SF) John Lynch said Friday morning that he expects McCaffrey (calf/Achilles) to play Monday against the Jets, Cam Inman of The San Jose Mercury News reports.

4:05 PM - Christian McCaffrey (SF) Kyle Shanahan said McCaffrey (calf/Achilles) will be a limited participant at Thursday's practice, Eric Branch of the San Francisco Chronicle reports.

2:24 PM - Christian McCaffrey (SF) (calf) is in uniform for the portion of Tuesday's practice open to the media, Matt Barrows of The Athletic reports.

9:15 AM - Christian McCaffrey (SF) (calf) is expected to return to practice Tuesday, Adam Schefter of ESPN reports.

4:43 PM - Christian McCaffrey (SF) (calf) increased his activity level on the side field at practice Thursday and seems to be getting closer to a return, Nick Wagoner of ESPN.com reports.

3:28 PM - Christian McCaffrey (SF) Kyle Shanahan said Tuesday that McCaffrey (calf) is nursing a calf strain and is unlikely to suit up for any preseason action, Matt Maiocco of NBC Sports Bay Area reports.

1:31 PM - Christian McCaffrey (SF) 49ers signed McCaffrey to a two-year, $38 million contract extension Tuesday, Adam Schefter of ESPN reports.

2:46 PM - Christian McCaffrey (SF) (calf) will be a full practice participant Tuesday, Matt Barrows of The Athletic reports.

6:48 PM - Christian McCaffrey (SF) (calf) will not practice this week, but head coach Kyle Shanahan expects him back next week leading up to the 49ers' Round 2 game, Nick Wagoner of ESPN.com reports.

5:36 PM - Christian McCaffrey (SF) Kyle Shanahan relayed Monday that McCaffrey is dealing with a mild calf strain and won't play Sunday against the Rams, Nick Wagoner of ESPN.com and Cam Inman of The San Jose Mercury News report.

10:20 AM - Christian McCaffrey (SF) right calf injury McCaffrey sustained in Sunday's victory over the Commanders could be minor, according to Nick Wagoner of ESPN.com.

4:35 PM - Christian McCaffrey (SF) Kyle Shanahan relayed after Sunday's 27-10 win over the Commanders that McCaffrey may be dealing with a calf strain, Eric Branch of the San Francisco Chronicle reports.

3:20 PM - Christian McCaffrey (SF) exited Sunday's game against the Commanders with a right calf injury and is questionable to return.

4:21 PM - Christian McCaffrey (SF) rushed 16 times for 95 yards and caught six of 10 targets for 47 yards in Sunday's 34-3 win over Jacksonville.

8:03 PM - Christian McCaffrey (SF) rushed 12 times for 54 yards and a touchdown and brought in six of seven targets for 64 yards and another score in the 49ers' 34-17 loss to the Bengals on Sunday.

6:49 PM - Christian McCaffrey (SF) (oblique) is active for Monday's game in Minnesota, Lindsey Pallares of the 49ers' official site reports.

12:43 PM - Christian McCaffrey (SF) (oblique), who is officially listed as questionable, is expected to play Monday against Minnesota, Adam Schefter of ESPN reports.

11:22 AM - Christian McCaffrey (SF) (oblique) is trending toward being active Monday against the Vikings, Adam Schefter of ESPN reports.

5:18 PM - Christian McCaffrey (SF) (oblique) is listed as questionable for Monday's contest against the Vikings, Matt Maiocco of NBC Sports Bay Area reports.

4:02 PM - Christian McCaffrey (SF) (oblique) was spotted participating in Saturday's practice, Cam Inman of The San Jose Mercury News reports.

6:33 PM - Christian McCaffrey (SF) (oblique) didn't practice Friday, Eric Branch of the San Francisco Chronicle reports.

4:39 PM - Christian McCaffrey (SF) (oblique) was working on the side with San Francisco's training staff during the open portion of practice Friday, Nick Wagoner of ESPN.com reports.

3:55 PM - Christian McCaffrey (SF) Kyle Shanahan said Thursday that McCaffrey (oblique) won't take part in the 49ers' first official practice of Week 7 prep, Nick Wagoner of ESPN.com reports.

4:57 PM - Christian McCaffrey (SF) (oblique/rib) isn't considered to be dealing with a long-term injury and could have a chance at being available for Monday's game against the Vikings, Adam Schefter of ESPN reports.

5:21 PM - Christian McCaffrey (SF) (oblique/ribs) is undergoing an MRI on Monday, Matt Barrows of The Athletic reports.

5:47 PM - Christian McCaffrey (SF) Kyle Shanahan said after Sunday's 19-17 loss at Cleveland that McCaffrey suffered oblique and rib injuries during the contest, Nick Wagoner of ESPN.com reports.

3:52 PM - Christian McCaffrey (SF) (oblique) won't return to Sunday's game against the Browns following an evaluation in the locker room, Mary Kay Cabot of The Cleveland Plain Dealer reports.

3:24 PM - Christian McCaffrey (SF) exited Sunday's game at Cleveland due to an oblique injury, Nick Wagoner of ESPN.com reports.

8:05 PM - Christian McCaffrey (SF) took 20 carries for 106 yards and three touchdowns while catching seven of eight targets for 71 yards and another score in Sunday's 35-16 win over Arizona.

2:58 PM - Christian McCaffrey (SF) (calf) returned to practice Friday, Matt Barrows of The Athletic reports.

6:09 PM - Christian McCaffrey (SF) (calf), who didn't practice Thursday, told Matt Maiocco of NBC Sports Bay Area that there's "zero" chance that he doesn't play in Sunday's NFC Championship Game in Philadelphia.

2:52 PM - Christian McCaffrey (SF) Kyle Shanahan said McCaffrey (calf) won't participate in Thursday's practice, Matt Maiocco of NBC Sports Bay Area reports.

2:53 PM - Christian McCaffrey (SF) (calf) is considered day-to-day, but coach Kyle Shanahan said Monday that he expects to play in Sunday's NFC Championship Game against the Eagles, David Lombardi of The Athletic reports.

10:01 AM - Christian McCaffrey (SF) noted after Sunday's 19-12 win over the Cowboys in the divisional round that the right calf issue that resulted in him ceding snaps to backup Elijah Mitchell late in the contest is "all good" and won't affect his availability for this weekend's NFC Championship Game matchup with the Eagles, Cam Inman of The San Jose Mercury News reports. "I was fighting but made it through, made it through great," said. "[The calf] is nothing bad."

11:25 PM - Christian McCaffrey (SF) rushed 10 times for 35 yards and a touchdown and caught six of eight targets for 22 yards in Sunday's 19-12 playoff win over the Cowboys.

8:42 PM - Christian McCaffrey (SF) rushed 15 times for 119 yards and caught both of his targets for 17 yards and a touchdown in Saturday's 41-23 playoff win over Seattle.

5:20 PM - Christian McCaffrey (SF) (knee) doesn't have a designation for Saturday's wild-card game against the Seahawks, Matt Barrows of The Athletic reports.

7:59 PM - Christian McCaffrey (SF) (knee) practiced in a limited fashion Wednesday.

6:58 PM - Christian McCaffrey (SF) (ankle/knee) was a limited participant at Tuesday's practice, Eric Branch of the San Francisco Chronicle reports.

5:12 PM - Christian McCaffrey (SF) (ankle/knee) has no injury designation for Sunday's game against the Cardinals, Matt Maiocco of NBC Sports Bay Area reports.

4:32 PM - Christian McCaffrey (SF) (ankle/knee) returned to practice Friday, Matt Barrows of The Athletic reports.

7:36 PM - Christian McCaffrey (SF) (ankle/knee) didn't practice Thursday, Matt Maiocco of NBC Sports Bay Area reports.

3:30 PM - Christian McCaffrey (SF) (ankle) won't take part in Wednesday's practice, David Lombardi of The Athletic reports.

6:50 PM - Christian McCaffrey (SF) is considered day-to-day with a mild ankle sprain, Cam Inman of The San Jose Mercury News reports.

8:54 PM - Christian McCaffrey (SF) rushed 19 times for 121 yards and a touchdown while adding six receptions on nine targets for 72 yards in Sunday's 34-31 overtime win over Las Vegas.

4:46 PM - Christian McCaffrey (SF) (knee) doesn't have an injury designation for Sunday's game against the Raiders, Jennifer Lee Chan of NBC Sports Bay Area reports.

7:08 PM - Christian McCaffrey (SF) (knee) was limited at Thursday's practice, Eric Branch of the San Francisco Chronicle reports.

3:08 PM - Christian McCaffrey (SF) (knee) will be a limited practice participant Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports.

9:19 PM - Christian McCaffrey (SF) rushed 15 times for 46 yards and a touchdown while chipping in two receptions for 12 yards in Saturday's 37-20 win over Washington.

5:11 PM - Christian McCaffrey (SF) (knee) doesn't have a designation for Saturday's contest against the Commanders, Nick Wagoner of ESPN.com reports.

7:05 PM - Christian McCaffrey (SF) (knee) practiced in a limited fashion Wednesday, Nick Wagoner of ESPN.com reports.

3:40 PM - Christian McCaffrey (SF) (knee) will be a limited practice participant Tuesday, Cam Inman of The San Jose Mercury News reports.

11:45 PM - Christian McCaffrey (SF) rushed 26 times for 108 yards and a touchdown while bringing in six of eight targets for 30 yards in the 49ers' 21-13 win over the Seahawks on Thursday night.

4:40 PM - Christian McCaffrey (SF) (knee) doesn't have an injury designation for Thursday's game against Seattle, Jennifer Lee Chan of NBC Sports Bay Area reports.

6:28 PM - Christian McCaffrey (SF) (knee) was listed as limited on Monday's practice estimate,Nick Wagoner of ESPN.com reports.

8:22 PM - Christian McCaffrey (SF) rushed 14 times for 119 yards and a touchdown while adding two receptions (three targets) for 34 yards and a receiving touchdown in Sunday's 35-7 rout of the Buccaneers.

5:05 PM - Christian McCaffrey (SF) (knee) doesn't have an injury designation for Sunday's game against the Buccaneers, Matt Maiocco of NBC Sports Bay Area reports.

7:14 PM - Christian McCaffrey (SF) (knee) practiced on a limited basis Thursday, Eric Branch of the San Francisco Chronicle reports.

6:18 PM - Christian McCaffrey (SF) was limited in practice Wednesday due to a knee injury, Eric Branch of the San Francisco Chronicle reports.

8:03 PM - Christian McCaffrey (SF) (knee) carried the ball 17 times for 66 yards while adding eight receptions (10 targets) for 80 yards and a touchdown in Sunday's 33-17 win over the Dolphins.