3:40 PM - Brandon Aiyuk (SF) 49ers placed Aiyuk (knee) on injured reserve Wednesday.

6:46 PM - Brandon Aiyuk (SF) Kyle Shanahan confirmed Monday that Aiyuk sustained tears to the ACL and MCL in his right knee during Sunday's loss to the Chiefs, Nick Wagoner of ESPN.com reports.

5:30 PM - Brandon Aiyuk (SF) reportedly suffered a torn ACL and MCL during Sunday's loss to the Chiefs, according to Ian Rapoport of NFL Network.

4:22 PM - Brandon Aiyuk (SF) tests on his injured knee Monday revealed a season-ending injury, Jordan Schultz of Fox Sports reports.

8:00 PM - Brandon Aiyuk (SF) Kyle Shanahan said after Sunday's 28-18 loss to the Chiefs that the 49ers are worried that Aiyuk tore his ACL, Adam Schefter of ESPN reports.

6:16 PM - Brandon Aiyuk (SF) won't return to Sunday's contest against the Chiefs due to a knee injury, Cam Inman of The San Jose Mercury News reports.

6:05 PM - Brandon Aiyuk (SF) went to the locker room on a cart due to an undisclosed injury at halftime of Sunday's game against the Chiefs, Eric Branch of the San Francisco Chronicle reports.

9:37 AM - Brandon Aiyuk (SF) is expected to serve as the 49ers' No. 1 receiver for at least Sunday's game against the Rams after San Francisco head coach Kyle Shanahan said Monday that Deebo Samuel (calf) is likely to miss "a couple weeks," Ron Kroichick of the San Francisco Chronicle reports.

6:12 PM - Brandon Aiyuk (SF) had four receptions (five targets) for 43 yards in Sunday's 23-17 loss to Minnesota.

5:07 PM - Brandon Aiyuk (SF) coach Kyle Shanahan said Saturday he'd be "surprised" if Aiyuk saw a full workload in the season opener Monday against the Jets, Eric Branch of the San Francisco Chronicle reports.

6:48 PM - Brandon Aiyuk (SF) 49ers and Aiyuk reached an agreement on a four-year, $120 million extension Thursday, Mike Garafolo of NFL Network reports.

1:52 PM - Brandon Aiyuk (SF) is not present at Thursday's practice, Nick Wagoner of ESPN.com reports.

6:36 PM - Brandon Aiyuk (SF) is not present at the portion of Wednesday's practice open to the media, though coach Kyle Shanahan said there was hope the wideout would resume participating soon, Cam Inman of The San Jose Mercury News reports.

5:15 PM - Brandon Aiyuk (SF) Kyle Shanahan suggested Wednesday that Aiyuk (contract dispute) could resume practicing soon, noting that he wideout has been "cleared by our doctors," David Lombardi of The Athletic reports.

11:23 AM - Brandon Aiyuk (SF) GM John Lynch said Thursday that he has no update on Aiyuk but remains in contract with the wide receiver, Eric Branch of the San Francisco Chronicle reports.

12:34 PM - Brandon Aiyuk (SF) 49ers are trying to work out a contract with Aiyuk but also have agreed to parameters of a trade with the Steelers, ESPN.com reports.

4:50 PM - Brandon Aiyuk (SF) and the 49ers have re-opened negotiations on a potential long-term deal that would keep the star wideout in San Francisco for the foreseeable future, Tom Pelissero of NFL Network reports.

10:35 AM - Brandon Aiyuk (SF) Patriots are no longer exploring a trade for Aiyuk, Adam Schefter of ESPN reports.

3:15 PM - Brandon Aiyuk (SF) Steelers and 49ers have re-engaged in trade talks Tuesday regarding a potential deal for Aiyuk, Adam Schefter of ESPN reports.

9:51 AM - Brandon Aiyuk (SF) 49ers have a framework in place to trade Aiyuk to the Patriots or Browns if he can agree to a contract with either team, Eric Branch of the San Francisco Chronicle reports.

9:31 AM - Brandon Aiyuk (SF) 49ers aren't likely to trade Aiyuk for only draft picks but may be willing to deal him if a veteran wide receiver is part of the return, Matt Maiocco of the NBC Sports Bay Area reports.

1:59 PM - Brandon Aiyuk (SF) is present at training camp Wednesday but isn't dressed for practice, Eric Branch of the San Francisco Chronicle reports.

1:49 PM - Brandon Aiyuk (SF) who officially requested a trade last week, is present for the start of 49ers training camp Tuesday, Ian Rapoport of NFL Network reports.

12:19 PM - Brandon Aiyuk (SF) GM Adam Peters said Aiyuk is unlikely to end up in Washington, Sam Fortier of The Washington Post reports.

1:20 PM - Brandon Aiyuk (SF) officially requested a trade from the 49ers on Tuesday, Mike Garafolo of NFL Network reports.

10:40 AM - Brandon Aiyuk (SF) recently told The Pivot podcast that he wants and expects to play for the 49ers this season despite being frustrated with contract negotiations at times.

1:32 PM - Brandon Aiyuk (SF) and the 49ers had a meeting Monday which Tom Pelissero of NFL Network described as "good," and both sides are continuing to work toward a contract extension, Grant Gordon of NFL.com reports.

10:10 AM - Brandon Aiyuk (SF) expressed frustration Monday with contract negotiations, although the 49ers remain interested in re-signing him at a lower price than what he's looking for, Ian Rapoport of NFL Network reports.

2:12 PM - Brandon Aiyuk (SF) is not present at 49ers minicamp this week as he seeks a new contract, Ian Rapoport of NFL Network reports.

9:48 AM - Brandon Aiyuk (SF) remains away from team facilities for OTAs as he continues to negotiate for a contract extension, Kevin Patra of NFL.com reports.

2:41 PM - Brandon Aiyuk (SF) GM John Lynch recently told ESPN's Pat McAfee Show that he doesn't want to trade Aiyuk or Deebo Samuel despite taking Ricky Pearsall in the first round of the 2024 NFL Draft.

3:33 PM - Brandon Aiyuk (SF) John Lynch said Monday that the 49ers are having "good talks" with Aiyuk, who hasn't been at the team facility for the offseason program, Matt Barrows of The Athletic reports.

12:51 PM - Brandon Aiyuk (SF) agent, Ryan Williams of Athletes First, denied reports on social media Sunday that the wide receiver has requested a trade from the 49ers, Mike Garafolo of NFL Network reports.

12:29 PM - Brandon Aiyuk (SF) John Lynch said Monday that the 49ers have not engaged in trade discussions regarding Aiyuk and that both sides continue to have active talks about a contract extension, Matt Maiocco of NBC Sports Bay Area reports.

4:02 PM - Brandon Aiyuk (SF) general manager John Lynch said Tuesday at the NFL Scouting Combine that the team wants to sign Aiyuk to a long-term contract extension, Eric Branch of the San Francisco Chronicle reports.

5:10 PM - Brandon Aiyuk (SF) recorded seven receptions on eight targets for 114 yards and a touchdown in Sunday's 27-10 win over the Commanders.

5:09 PM - Brandon Aiyuk (SF) caught four of 10 targets for 76 yards in Sunday's 19-17 loss to Cleveland.

8:35 PM - Brandon Aiyuk (SF) (shoulder) corralled all six of his targets for 148 yards in Sunday's 35-16 win over the Cardinals.

5:01 PM - Brandon Aiyuk (SF) (shoulder) doesn't have an injury designation for Sunday's game against the Cardinals, Matt Barrows of The Athletic reports.

7:15 PM - Brandon Aiyuk (SF) (shoulder) was a limited participant at Thursday's practice, Nick Wagoner of ESPN.com reports.

4:32 PM - Brandon Aiyuk (SF) (shoulder) wasn't wearing a non-contact jersey at the start of Thursday's practice, Cam Inman of The San Jose Mercury News reports.

4:01 PM - Brandon Aiyuk (SF) (shoulder) was a limited participant in practice Wednesday, Matt Barrows of The Athletic reports.

5:51 PM - Brandon Aiyuk (SF) (shoulder) was present for Monday's practice, Cam Inman of The San Jose Mercury News reports.

6:49 PM - Brandon Aiyuk (SF) (shoulder) is listed as inactive Thursday against the Giants, Lindsey Pallares of the 49ers' official site reports.

4:39 PM - Brandon Aiyuk (SF) (shoulder), who is listed as questionable for Thursday's game against the Giants, isn't expected to play, Adam Schefter of ESPN reports.

3:41 PM - Brandon Aiyuk (SF) (shoulder) is listed as questionable for Thursday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports.

4:36 PM - Brandon Aiyuk (SF) Francisco head coach Kyle Shanahan said Aiyuk (shoulder) will be a limited participant in Tuesday's practice, Nick Wagoner of ESPN.com reports.

5:39 PM - Brandon Aiyuk (SF) (shoulder) was listed as a non-participant on Monday's practice estimation, Cam Inman of The San Jose Mercury News reports.

5:23 PM - Brandon Aiyuk (SF) caught all eight of his targets for 129 yards and two touchdowns in Sunday's 30-7 win over the Steelers.

3:03 AM - Brandon Aiyuk (SF) hauled in his lone target for 15 yards in Saturday's 21-20 preseason win over Denver.

9:21 PM - Brandon Aiyuk (SF) caught three of five targets for 73 yards in Saturday's 41-23 win over Seattle.

10:34 PM - Brandon Aiyuk (SF) had four receptions (five targets) for 59 yards in Sunday's 38-13 win over Arizona.

9:21 PM - Brandon Aiyuk (SF) had nine receptions (12 targets) for 101 yards and a touchdown while rushing once for 16 yards in Sunday's 37-34 win over the Raiders.

11:50 PM - Brandon Aiyuk (SF) hauled in five of seven targets for 81 yards in Saturday's 37-20 win over the Commanders.

8:35 PM - Brandon Aiyuk (SF) caught two of three targets for 57 yards and a touchdown in Sunday's 35-7 win over Tampa Bay.

8:35 PM - Brandon Aiyuk (SF) caught five of nine targets for 46 yards in Sunday's 33-17 win over the Dolphins.

10:10 PM - Brandon Aiyuk (SF) hauled in five of eight targets for 65 yards in Sunday's 13-0 win over New Orleans.

9:04 PM - Brandon Aiyuk (SF) corralled all six of his targets for 81 yards and a touchdown in Sunday's 31-14 win over the Rams.

11:20 PM - Brandon Aiyuk (SF) had seven receptions (11 targets) for 82 yards in Sunday's 44-23 loss to the Chiefs.

9:34 PM - Brandon Aiyuk (SF) corralled eight of 11 targets for 83 yards and two touchdowns in Sunday's 28-14 loss to the Falcons.

9:06 PM - Brandon Aiyuk (SF) caught three of four targets for 58 yards in Sunday's 37-15 win over the Panthers.

11:34 PM - Brandon Aiyuk (SF) caught all four of his targets for 37 yards in Monday's 24-9 win over the Rams.

9:01 PM - Brandon Aiyuk (SF) caught five of eight targets for 63 yards in Sunday's 27-7 win over the Seahawks.

1:15 PM - Brandon Aiyuk (SF) caught both of his targets for 40 yards and received one carry for seven yards in Sunday's 19-10 loss to the Bears.

1:15 PM - Brandon Aiyuk (SF) caught both of his targets for 40 yards and received one carry for seven yards in Sunday's 19-10 loss to the Bears.

11:38 PM - Brandon Aiyuk (SF) didn't catch his only target in Thursday's 17-0 loss to the Texans.

7:20 PM - Brandon Aiyuk (SF) is in uniform and appears set to play in Thursday's preseason game at Houston, Eric Branch of the San Francisco Chronicle reports.

6:14 PM - Brandon Aiyuk (SF) isn't expected to play in Saturday's preseason game against Minnesota, Cam Inman of The San Jose Mercury News reports.

8:28 PM - Brandon Aiyuk (SF) isn't slated to play in Friday's preseason game versus the Packers, Nick Wagoner of ESPN.com reports.

1:37 PM - Brandon Aiyuk (SF) has made a strong impression on teammates and reporters alike, with safety Jimmie Ward saying the wideout is "taking his game to another level" and ESPN's Nick Wagoner calling him "the team's most consistent offensive performer" at training camp.

1:37 PM - Brandon Aiyuk (SF) has made a strong impression on teammates and reporters alike, with safety Jimmie Ward saying the wideout is "taking his game to another level" and ESPN's Nick Wagoner calling him "the team's most consistent offensive performer" at training camp.

12:40 PM - Brandon Aiyuk (SF) has excelled in training camp for the 49ers, Jennifer Lee Chan of NBC Sports Bay Area reports.

12:40 PM - Brandon Aiyuk (SF) has excelled in training camp for the 49ers, Jennifer Lee Chan of NBC Sports Bay Area reports.

11:50 PM - Brandon Aiyuk (SF) hauled in four of eight targets for 69 yards in Sunday's 20-17 loss to the Rams.

10:22 PM - Brandon Aiyuk (SF) caught five of six targets for 66 yards in Sunday's 23-17 win over the Cowboys in the wild-card round.

10:44 PM - Brandon Aiyuk (SF) caught six of seven targets for 107 yards in Sunday's 27-24 win over the Rams.

9:15 PM - Brandon Aiyuk (SF) corralled four of six targets for 94 yards in Sunday's 23-7 win over the Texans.

9:59 PM - Brandon Aiyuk (SF) had one reception (two targets) for 36 yards in Sunday's 31-13 win over the Falcons.

10:54 PM - Brandon Aiyuk (SF) caught six of 11 targets for 62 yards and a touchdown in Sunday's 26-23 overtime win over the Bengals.

11:47 PM - Brandon Aiyuk (SF) caught three of six targets for 55 yards in Sunday's 30-23 loss to the Seahawks.

6:54 PM - Brandon Aiyuk (SF) should be key for the 49ers' passing game with fellow wide receiver Deebo Samuel (groin) ruled out for Sunday's contest in Seattle, Jerry McDonald of the Bay Area News Group reports.

11:16 PM - Brandon Aiyuk (SF) caught three of six targets for 91 yards in Sunday's 34-28 win over the Vikings.

4:44 PM - Brandon Aiyuk (SF) caught seven passes for 85 yards and one touchdown on seven targets against Jacksonville on Sunday.

11:39 PM - Brandon Aiyuk (SF) caught three of four targets for 26 yards in Monday night's 31-10 win over the Rams.

6:15 PM - Brandon Aiyuk (SF) had four receptions (seven targets) for 45 yards in Sunday's 33-22 win over the Bears.

4:28 PM - Brandon Aiyuk (SF) started and was on the field for 40 offensive snaps (71 percent), but only finished with one reception (one target) for six yards in Sunday's 30-18 loss to the Colts.

8:33 PM - Brandon Aiyuk (SF) caught two of four targets for 32 yards against Arizona on Sunday.

8:12 PM - Brandon Aiyuk (SF) caught one of three targets for a 15-yard reception against Seattle on Sunday.

5:45 PM - Brandon Aiyuk (SF) had one reception (two targets) for six yards in Sunday's 17-11 win over the Eagles.

4:11 PM - Brandon Aiyuk (SF) Kyle Shanahan said Aiyuk should see more playing time moving forward, as long as he stays healthy and regularly participates in practice, David Lombardi of The Athletic reports.

5:57 PM - Brandon Aiyuk (SF) (hamstring) -- who did not receive a target in Sunday's win over the Lions -- fell down the depth chart due to injury and not performance, David Lombardi of The Athletic reports.

6:45 PM - Brandon Aiyuk (SF) (hamstring) practiced fully Wednesday, Keiana Martin of the 49ers' official site reports.

2:36 PM - Brandon Aiyuk (SF) (hamstring) ran routes and caught passes during the part of Monday's practice open to the media, Nick Wagoner of ESPN.com reports.

3:04 PM - Brandon Aiyuk (SF) (hamstring) looked unencumbered while running sprints on a side field Thursday, and he's on track to be a full-go Week 1 at Detroit, Michael-Shawn Dugar of The Athletic reports.

6:43 PM - Brandon Aiyuk (SF) (hamstring) didn't take part of the part of Wednesday's practice open to the media, Nick Wagoner of ESPN.com reports.

4:52 PM - Brandon Aiyuk (SF) is dealing with what's being described as a slight hamstring issue, Nick Wagoner of ESPN.com reports.

11:25 PM - Brandon Aiyuk (SF) caught one of three targets for three yards in Sunday's 15-10 preseason win over the Chargers.

3:37 PM - Brandon Aiyuk (SF) did not take part in Wednesday's OTA due to a minor groin injury, Matt Barrows of The Athletic reports.

5:47 PM - Brandon Aiyuk (SF) who suffered a high-ankle sprain in this past Saturday's win over the Cardinals, won't play in Sunday's season finale against the Seahawks, Nick Wagoner of ESPN.com reports.

8:38 PM - Brandon Aiyuk (SF) recorded one reception on two targets for 15 yards in Week 16 against the Cardinals. He added one rushing attempt for 16 yards.