Anaheim Ducks
| Robby Fabbri (RW / LW) | Upper body injury | injured reserve |
| Ross Johnston (LW / RW) | Upper body injury | day-to-day |
| Brock McGinn (LW / RW) | ACL surgery | injured reserve |
Boston Bruins
| Mark Kastelic (RW / C) | Upper body injury | sidelined indefinitely |
| Hampus Lindholm (D) | Knee surgery | injured reserve |
| Charlie McAvoy (D) | Shoulder injury - right | injured reserve |
Buffalo Sabres
| Jordan Greenway (LW / C) | Lower body injury | day-to-day |
| Sam Lafferty (RW / C) | Groin injury | day-to-day |
| Joshua Norris (C) | Undisclosed | day-to-day |
Calgary Flames
| Justin Kirkland (RW / C) | ACL surgery | injured reserve |
| Anthony Mantha (RW / LW) | ACL surgery | injured reserve |
| Connor Zary (W / C) | Knee injury | sidelined indefinitely |
Carolina Hurricanes
| William Carrier (LW / RW) | Lower body surgery | sidelined indefinitely |
| Jesper Fast (RW) | Neck surgery | injured reserve |
Chicago Blackhawks
| Laurent Brossoit (G) | Knee surgery | injured reserve |
| Colton Dach (W / C) | Elbow hyperextension - left | sidelined indefinitely |
| Jason Dickinson (C / LW) | Wrist injury | remainder of the regular season |
| Alec Martinez (D) | Upper body injury | day-to-day |
Colorado Avalanche
| Erik Johnson (D) | Lower body injury | day-to-day |
| Joel Kiviranta (LW / RW) | Lower body injury | day-to-day |
| Gabriel Landeskog (LW) | Knee injury | injured reserve |
| Josh Manson (D) | Upper body injury | week-to-week |
| Tucker Poolman (D) | Head injury | injured reserve |
Columbus Blue Jackets
| Kevin Labanc (RW) | Shoulder surgery | injured reserve |
| Owen Sillinger (C / LW) | Knee injury | injured reserve |
Dallas Stars
| Miro Heiskanen (D) | Knee surgery | injured reserve |
| Nils Lundkvist (D) | Shoulder surgery | injured reserve |
| Tyler Seguin (RW / C) | Hip surgery | injured reserve |
Detroit Red Wings
| Andrew Copp (C / LW) | Pectoral surgery | injured reserve |
| Erik Gustafsson (D) | Undisclosed | sidelined indefinitely |
| Carter Mazur (RW / LW) | Upper body injury | injured reserve |
| Petr Mrazek (G) | Undisclosed | day-to-day |
| Elmer Soderblom (LW / RW) | Undisclosed | day-to-day |
Edmonton Oilers
| Leon Draisaitl (C / W) | Undisclosed | week-to-week |
| Mattias Ekholm (D) | Undisclosed | day-to-day |
| Trent Frederic (W / C) | Lower body injury | injured reserve |
| Evander Kane (LW) | Knee surgery | injured reserve |
| Connor McDavid (C) | Lower body injury | week-to-week |
| Stuart Skinner (G) | Undisclosed | day-to-day |
Florida Panthers
| Dmitry Kulikov (D) | Upper body injury | week-to-week |
| Matthew Tkachuk (RW / LW) | Groin injury | injured reserve |
Los Angeles Kings
| Tanner Jeannot (LW / RW) | Undisclosed | day-to-day |
| Alex Turcotte (W / C) | Upper body injury | day-to-day |
Minnesota Wild
| Declan Chisholm (D) | Lower body injury | day-to-day |
| Joel Eriksson Ek (C) | Lower body injury | injured reserve |
| Kirill Kaprizov (LW) | Lower body surgery | injured reserve |
Montreal Canadiens
| Kirby Dach (C / RW) | Knee surgery - right | injured reserve |
Nashville Predators
| Roman Josi (D) | Upper body injury | injured reserve |
| Jeremy Lauzon (D) | Lower body injury | injured reserve |
| Adam Wilsby (D) | Upper body injury | injured reserve |
New Jersey Devils
| Cody Glass (C / RW) | Undisclosed | day-to-day |
| Dougie Hamilton (D) | Lower body injury | remainder of the regular season |
| Luke Hughes (D) | Lower body injury | day-to-day |
| Jack Hughes (C / LW) | Shoulder surgery - right | injured reserve |
| Jonas Siegenthaler (D) | Lower body surgery | injured reserve |
New York Islanders
| Mathew Barzal (RW / C) | Knee surgery | injured reserve |
| Semyon Varlamov (G) | Lower body injury | injured reserve |
New York Rangers
| Adam Edstrom (LW / C) | Lower body injury | injured reserve |
| Arthur Kaliyev (RW / LW) | Upper body injury | remainder of the playoffs |
| Matt Rempe (RW / C) | Upper body injury | week-to-week |
Ottawa Senators
| Nick Cousins (LW / RW) | Knee surgery | injured reserve |
Philadelphia Flyers
| Garnet Hathaway (RW) | Upper body injury | day-to-day |
| Rasmus Ristolainen (D) | Upper body injury | sidelined indefinitely |
Pittsburgh Penguins
| Bokondji Imama (LW) | Upper body injury | day-to-day |
| P.O Joseph (D) | Upper body injury | injured reserve |
| Evgeni Malkin (C / LW) | Upper body injury | day-to-day |
| Thomas Novak (C / LW) | Lower body injury | day-to-day |
San Jose Sharks
| Logan Couture (C) | Groin injury | injured reserve |
| Jan Rutta (D) | Lower body injury | injured reserve |
| Henry Thrun (D) | Upper body injury | day-to-day |
| Marc-Edouard Vlasic (D) | Upper body injury | day-to-day |
Seattle Kraken
| Chandler Stephenson (C / LW) | Upper body injury | day-to-day |
St. Louis Blues
| Torey Krug (D) | Ankle surgery - left | injured reserve |
| Colton Parayko (D) | Arthroscopic knee surgery - left | sidelined indefinitely |
Toronto Maple Leafs
| Jani Hakanpaa (D) | Knee injury | injured reserve |
| Max Pacioretty (LW / RW) | Undisclosed | injured reserve |
Utah Hockey Club
| Robert Bortuzzo (D) | Lower body injury | injured reserve |
| Liam O'Brien (LW / RW) | Lower body injury | sidelined indefinitely |
Vancouver Canucks
| Filip Chytil (C) | Concussion | sidelined indefinitely |
| Nils Hoglander (LW / RW) | Undisclosed | day-to-day |
| Noah Juulsen (D) | Sports hernia surgery | injured reserve |
| Elias Pettersson (C / W) | Undisclosed | day-to-day |
Vegas Golden Knights
| Tomas Hertl (C / LW) | Shoulder injury | day-to-day |
| Alex Pietrangelo (D) | Lower body injury | day-to-day |
Washington Capitals
| Sonny Milano (LW / RW) | Upper body injury | injured reserve |
| T.J. Oshie (RW) | Back injury | injured reserve |
Winnipeg Jets
| Rasmus Kupari (C / RW) | Post concussion syndrome | day-to-day |
| Neal Pionk (D) | Lower body injury | week-to-week |
| Gabriel Vilardi (RW) | Upper body injury | week-to-week |