6:53 PM - A.J. Epenesa (Buf) recorded three total tackles (two solo), including 1.0 sacks, and defended one pass in Sunday's 34-10 win over the Titans.

8:00 PM - A.J. Epenesa (Buf) recorded four tackles (three solo), including 2.0 sacks, in the Bills' win over the Jets on Monday night.

7:15 PM - A.J. Epenesa (Buf) and the Bills agreed on a two-year contract worth up to $20 million Monday, Mike Garafolo of NFL Network reports.

12:09 PM - A.J. Epenesa (Buf) (ribs) is active for Sunday's game versus the Patriots.

4:58 PM - A.J. Epenesa (Buf) (ribs) is listed as questionable ahead of Sunday's game against the Patriots.

3:27 PM - A.J. Epenesa (Buf) was listed as limited for the second straight day Thursday due to a rib injury.

3:38 PM - A.J. Epenesa (Buf) (rib) is listed as questionable ahead of Saturday's game against the Chargers.

4:32 PM - A.J. Epenesa (Buf) (ribs) was listed as limited on Tuesday's practice estimate.

11:40 AM - A.J. Epenesa (Buf) Sean McDermott said Friday that Epenesa (ribs) is ruled out for Sunday's game against the Cowboys, Alaina Getzenberg of ESPN.com reports.

6:37 PM - A.J. Epenesa (Buf) (ribs) remained sidelined for Thursday's practice.

12:39 PM - A.J. Epenesa (Buf) (ribs) should still be considered week-to-week, according to head coach Sean McDermott, and the Bills are still gathering information Wednesday as to whether a stint on injured reserve is an option, Jon Scott of Spectrum News 1 reports.

4:30 PM - A.J. Epenesa (Buf) is week-to-week, according to head coach Sean McDermott, after suffering a rib injury in Sunday's win over the Chiefs, Katherine Fitzgerald of The Buffalo News reports.

5:03 PM - A.J. Epenesa (Buf) is doubtful to return to Sunday's game versus the Chiefs with a rib injury.

4:42 PM - A.J. Epenesa (Buf) (ribs) has been cleared to return to Sunday's game against the Chiefs.

4:40 PM - A.J. Epenesa (Buf) (ribs) is questionable to return to Sunday's game against the Chiefs.

3:57 PM - A.J. Epenesa (Buf) (ankle) was a full participant in practice Monday.

11:07 AM - A.J. Epenesa (Buf) (ankle) is inactive for Thursday's contest against the Lions.

11:26 AM - A.J. Epenesa (Buf) (ankle) is considered doubtful to play Thursday versus the Lions, Alaina Getzenberg of ESPN.com reports.

2:47 PM - A.J. Epenesa (Buf) (ankle) was downgraded to out for the remainder of Sunday's contest against Cleveland.

1:42 PM - A.J. Epenesa (Buf) is questionable to return to Sunday's game against the Browns with an ankle injury.

12:47 PM - A.J. Epenesa (Buf) is expected to start Sunday's matchup against Minnesota in the absence of Greg Rousseau (ankle), Joe Buscaglia of The Athletic reports.

4:28 PM - A.J. Epenesa (Buf) (ankle) is no longer on the Bills' injury report Wednesday.

11:27 AM - A.J. Epenesa (Buf) Bills activated Epenesa (ankle) from the reserve/COVID-19 list Wednesday.

7:16 PM - A.J. Epenesa (Buf) (ankle) was placed on the reserve/COVID-19 list Monday, Chris Jenkins of the Bills' official site reports.

11:38 AM - A.J. Epenesa (Buf) (ankle) is inactive Week 15 against Carolina.

5:17 PM - A.J. Epenesa (Buf) (ankle) is questionable for Sunday against the Panthers.

7:03 PM - A.J. Epenesa (Buf) (foot) is active for Sunday night's game against the Chiefs.

8:27 PM - A.J. Epenesa (Buf) (foot) practiced on a limited basis for a second straight day Friday and is listed as questionable for Sunday's game in Kansas City.

4:52 PM - A.J. Epenesa (Buf) practiced on a limited basis Thursday due to a foot injury.

8:18 PM - A.J. Epenesa (Buf) who struggled to transform his body for the pro game in his rookie season, has heads into 2021 in fantastic shape and weight, Chris Brown of the Bills' official site reports. Said defensive coordinator Leslie Frazier, "He's more explosive. He's really benefited from staying here which was something he couldn't do last offseason, because of all the things that were going on. I'm anxious to see once we get to training camp if some of the things that we're seeing now transfer to what we're going to do when we put pads on. But, man, he looks really, really good at this point."

3:29 PM - A.J. Epenesa (Buf) (head) practiced fully again Saturday and does not have an injury designation for Monday's game at New England.

3:31 PM - A.J. Epenesa (Buf) who exited the Week 15 win over the Broncos, was listed as a full participant on Thursday's practice report.

6:10 PM - A.J. Epenesa (Buf) who had to leave the team's Week 9 contest against the Cardinals with a concussion, was able to practice fully Wednesday.

5:49 PM - A.J. Epenesa (Buf) was ruled out for the rest of Sunday's game versus the Cardinals after suffering a concussion.

5:41 PM - A.J. Epenesa (Buf) is being evaluated for a head injury during Sunday's game against the Cardinals.

11:37 AM - A.J. Epenesa (Buf) has been made a game-day inactive for Sunday's game against the Jets.

1:41 PM - A.J. Epenesa (Buf) signed his four-year rookie contract with the Bills on Friday, Field Yates of ESPN reports.

8:52 PM - A.J. Epenesa (Buf) Bills selected Epenesa in the second round of the 2020 NFL Draft, 54th overall.