4:20 PM - Isaac Guerendo (SF) (foot, hamstring) has been ruled out for Sunday's game at Miami, Matt Maiocco of NBC Sports Bay Area reports.

12:10 PM - Isaac Guerendo (SF) 49ers are not expected to have Guerendo (hamstring) available for Sunday's game against the Dolphins, Adam Schefter of ESPN reports.

2:49 PM - Isaac Guerendo (SF) (hamstring) will not practice Wednesday, David Lombardi of SFStandard.com reports.

6:49 PM - Isaac Guerendo (SF) (foot) is listed as active Thursday against the Rams, Lindsey Pallares of the 49ers' official site reports.

9:47 AM - Isaac Guerendo (SF) (foot) remains listed as questionable for Thursday's game against the Rams but insists he "feels good" and plans to play, sources tell Adam Schefter of ESPN.

4:32 PM - Isaac Guerendo (SF) (foot) is listed as questionable for Thursday's game versus the Rams, Eric Branch of the San Francisco Chronicle reports.

4:38 PM - Isaac Guerendo (SF) (foot) won't participate in Tuesday's walk-through practice, Nick Wagoner of ESPN.com reports.

3:50 PM - Isaac Guerendo (SF) head coach Kyle Shanahan said Monday that Guerendo has been diagnosed with a foot sprain and will be considered day-to-day heading into Thursday's game against the Rams, Nick Wagoner of ESPN.com reports.

5:05 PM - Isaac Guerendo (SF) Christian McCaffrey (knee) and Jordan Mason (ankle) in line to be placed on injured reserve, Guerendo is expected to take over as the 49ers' starting running back, Adam Schefter of ESPN reports.

2:55 PM - Isaac Guerendo (SF) took four carries for 19 yards and a touchdown while losing three yards on his only reception in Sunday's 35-10 loss to the Bills.

1:50 PM - Isaac Guerendo (SF) had one carry for zero yards in Sunday's 23-20 win over Tampa Bay.

5:06 PM - Isaac Guerendo (SF) rushed five times for 22 yards and was not targeted as a receiver in Sunday's 24-23 loss to Arizona.

7:29 PM - Isaac Guerendo (SF) lost a fumble on his lone carry Sunday, failing to gain any yards while earning zero targets in a blowout win over the Patriots.

3:11 PM - Isaac Guerendo (SF) rushed five times for 19 yards in Sunday's 27-24 loss to the Rams.

5:20 PM - Isaac Guerendo (SF) (groin) suited up for Monday's season opener against the Jets but did not record a touch in the 32-19 win.

6:11 PM - Isaac Guerendo (SF) (groin) practiced in full Saturday and doesn't have an injury designation for Monday's Week 1 contest against the Jets.

6:44 PM - Isaac Guerendo (SF) (groin) remained limited in practice Friday, Nick Wagoner of ESPN.com reports.

4:57 PM - Isaac Guerendo (SF) (groin) is practicing on a limited basis Thursday, Cam Inman of The San Jose Mercury News reports.

5:18 PM - Isaac Guerendo (SF) tweaked his groin Monday and won't practice this week, Cam Inman of The San Jose Mercury News reports.

3:47 AM - Isaac Guerendo (SF) (hamstring) rushed 11 times for 32 yards and caught both of his targets for three yards in Friday's preseason tilt against Las Vegas.

3:11 PM - Isaac Guerendo (SF) (hamstring) will retake the practice field Tuesday, Nick Wagoner of ESPN.com reports.

1:40 PM - Isaac Guerendo (SF) Kyle Shanahan said Sunday he's "hopeful" Guerendo (hamstring) will be able to resume practicing this week and potentially play in Friday's preseason finale against the Raiders, Matt Barrows of The Athletic reports.

3:53 PM - Isaac Guerendo (SF) is expected to be sidelined multiple weeks due to the hamstring injury he sustained last week, Adam Schefter of ESPN reports.

3:19 PM - Isaac Guerendo (SF) (hamstring) departed Wednesday's training camp practice early, Jennifer Lee Chan of NBC Sports Bay Area reports.