Sports Forecaster 
Indianapolis Colts
0-2-0 4th in AFC SouthSeptember 25, 2021
| Brett Hundley (QB) | Activated from the practice squad by the Indianapolis Colts. |
| DeMichael Harris (WR) | Activated from the practice squad by the Indianapolis Colts. |
September 24, 2021
| Antwaun Woods (NT/DT) | Signed by the Indianapolis Colts from the practice squad. |
| Braden Smith (OT/OG) | Foot, Thumb, out. |
| Jordan Glasgow (LB/S) | Concussion, reserve/injured. |
September 20, 2021
| DeMichael Harris (WR) | Reverted back to the Indianapolis Colts practice squad. |
| Week # | Date | Opponent | Time [ ET ] | |||
|---|---|---|---|---|---|---|
| 3 | Sunday, Sep. 26 | @ |
|
Tennessee | 1:00 PM | |
| 4 | Sunday, Oct. 3 | @ |
|
Miami | 1:00 PM | |
| 5 | Monday, Oct. 11 | @ |
|
Baltimore | 8:15 PM | |
| 6 | Sunday, Oct. 17 |
|
Houston | 1:00 PM | ||
| 7 | Sunday, Oct. 24 | @ |
|
San Francisco | 8:20 PM | |